anythingforpink
September 1st, 2013, 07:50 PM
Hi there,
I am new to the boards and just completed my first IVF cycle, which failed. We are devastated and I am hoping that some of you ladies may have some insight or at least have heard of this happening.
I have 2 boys, ages 4 and 2 and have desperately wanted a little girl forever. My DH and I embarked on the IVF/PGD journey several months back to ensure that our third child would be a girl, since neither one of us would like to have more than 3 children. I am 34, DH is 37. Neither one us has any known fertility issues. We got pregnant with my oldest son on the first try, and with my second son on the second try. All of the tests we took before starting medication came back as "normal"...
I started stims on Aug 16th (gonal-f and menopur, and then eventually ganirelix). I responded well and had 16 eggs retrieved during ER. 14 of the 16 were mature and all 14 were successfully fertilized with ICSI. All 14 were biopsied on day 3 for aCGH. All embryos survived the biopsy on day 5, the morning of the transfer.
While I am on the table, naked from the waist down, having an U/S tech check my bladder every 5 minutes, the doctor comes in with the report from Reprogenetics, saying that he has the report and the news "may not be what I want to hear."
He scans through the report VERY quickly, and basically tells me that out of 14 embryos, only 3 were girls. Of the 14 embryos, only 3 were normal. None of the 3 normal embryos were girls. So we had nothing to transfer. I was shocked. Partly at how nearly 80% were boys, but more so that nearly 80% were abnormal. I burst in tears, and the doctor excused himself.
A few minutes later, he returned and my husband asked him a lot of questions related to the accuracy of the tests. The doctor assured him it was "very accurate--as accurate as it gets". DH asked him how it was possible that we would have SO many abnormal embryos. The doctor blamed it on my age even though I am under 35. I asked what would happen if we transferred one of the girl embryos. The doctor said no pregnancy or a miscarriage. We felt as thought we exhausted everything and we left.
Later, I researched a bit and found that in many cases, day 3 was not necessarily the most reliable method of testing and normal embryos can sometimes be identified as abnormal on day 3 when they are not, partly due to the small amount of DNA analyzed..I feel sick thinking we discarded so many embryos that COULD have been normal. I am upset that the option to re-biopsy on day 5 was not offered to us.. We are considering doing another cycle, this time with a day 5 biopsy, but wonder if we would get the same results. I have so many questions, and figured I would ask here to see if anyone had any advice or past experiences that might help to clear this up!
Thanks in advance!
I am new to the boards and just completed my first IVF cycle, which failed. We are devastated and I am hoping that some of you ladies may have some insight or at least have heard of this happening.
I have 2 boys, ages 4 and 2 and have desperately wanted a little girl forever. My DH and I embarked on the IVF/PGD journey several months back to ensure that our third child would be a girl, since neither one of us would like to have more than 3 children. I am 34, DH is 37. Neither one us has any known fertility issues. We got pregnant with my oldest son on the first try, and with my second son on the second try. All of the tests we took before starting medication came back as "normal"...
I started stims on Aug 16th (gonal-f and menopur, and then eventually ganirelix). I responded well and had 16 eggs retrieved during ER. 14 of the 16 were mature and all 14 were successfully fertilized with ICSI. All 14 were biopsied on day 3 for aCGH. All embryos survived the biopsy on day 5, the morning of the transfer.
While I am on the table, naked from the waist down, having an U/S tech check my bladder every 5 minutes, the doctor comes in with the report from Reprogenetics, saying that he has the report and the news "may not be what I want to hear."
He scans through the report VERY quickly, and basically tells me that out of 14 embryos, only 3 were girls. Of the 14 embryos, only 3 were normal. None of the 3 normal embryos were girls. So we had nothing to transfer. I was shocked. Partly at how nearly 80% were boys, but more so that nearly 80% were abnormal. I burst in tears, and the doctor excused himself.
A few minutes later, he returned and my husband asked him a lot of questions related to the accuracy of the tests. The doctor assured him it was "very accurate--as accurate as it gets". DH asked him how it was possible that we would have SO many abnormal embryos. The doctor blamed it on my age even though I am under 35. I asked what would happen if we transferred one of the girl embryos. The doctor said no pregnancy or a miscarriage. We felt as thought we exhausted everything and we left.
Later, I researched a bit and found that in many cases, day 3 was not necessarily the most reliable method of testing and normal embryos can sometimes be identified as abnormal on day 3 when they are not, partly due to the small amount of DNA analyzed..I feel sick thinking we discarded so many embryos that COULD have been normal. I am upset that the option to re-biopsy on day 5 was not offered to us.. We are considering doing another cycle, this time with a day 5 biopsy, but wonder if we would get the same results. I have so many questions, and figured I would ask here to see if anyone had any advice or past experiences that might help to clear this up!
Thanks in advance!