Maternit21 was wrong for gender?! Told boy; it's a girl?

[icefloe00]

Hi! Being 36 for my second pregnancy, I was offered the Maternit21 test at 10 weeks. Wonderfully, we got back negative results for the trisomies, and as a bonus we were told the gender. They told us it was a boy with 99.4% accuracy. Fast forward to 20 weeks, and the ultrasound clearly shows a girl - we saw the three lines/no penis, and the tech filled out our paperwork as being female. We have a large blended family with no girls, so to say I am in a state of shock is an understatement.

Has anyone heard of this happening? I feel pretty confident with what we saw on the screen, but can't figure out how the test would detect enough fetal Y chromosome to say boy, when it seems there should be no y chromosome at all! I did have a boy a few years ago, but it seems strange there would still be enough residual Y from him.

I will be discussing with midwives next week, but in the meantime am totally confused!

[WantingPink]

Do you have a potty shot? I would call them and discuss the findings with someone who is technical and can explain the results. What was your percentage of fetal DNA found? No test is 100%, not even an amnio. 99.4% means that 6 in every 1000 will be incorrect. My worst fear has always been a sample or reporting mix up. This is really awful and I would want to get to the bottom of what happened. I can tell you that it ISN'T residual Y chromosome from your son. Maybe they will retest you for free if you are really confident in the ultrasound results??

[nuthinbutpink]

I really don't think the tests are accurate for gender. You are not the first!

[Mrs_Incredible]

Oh no. I was told healthy girl yesterday on the harmony blood test I had done at 12+5 ..... Now I feel my bubble has burst :( They should retest for free. Xx


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[WantingPink]

The fact is WAY more of these have been correct than incorrect. If your results are incorrect then you aren't the first nor the last however, to say the tests aren't accurate for gender just isn't true. Under that definition there is NO accurate test available.

The 99.4% comes from testing thousands of specimens and following up with an amnio and then following up again at birth. The test doesn't claim to be 100%. On this forum I haven't personally seen any inaccurate for gender however, I did see one that was reported out as Turners and turned out to be normal which is different than a wrong gender. I have also seen one that they thought it wasn't accurate when actually it was the ultrasound that was incorrect. The moderators may have more information or statistics on accuracy that I don't have access to in which case they should make that information public if it is available.

I personally would want to see the test results that were reported to my provider. Maybe they got your paperwork mixed up with someone else? There are so many places for error. I would contact Sequenom. They can probably pull records from your test and if everything seems to check out then I would ask that my specimen be retested because it is just as likely that your specimen was switched with another patient or your results were reported in error which are human errors not testing errors. Please follow up with Sequenom and follow up with this thread as I know there will be lots of people who will want to know the outcome and reason for the discrepancy.

[icefloe00]

Thank you! I will be speaking with my midwives first thing this week, and following up with Sequenom as well, thanks to your suggestion. We saw lots of potty shots during the ultrasound, but did not get a printed one – the tech seemed to be lingering there for quite a while, probably because we told her Mat21 said boy. Foolishly, we didn't ask much at the time, feeling so sure of the Mat21 results (despite not seeing a penis!). We didn't get the female confirmation until the u/s report went to our midwife practice this weekend.

I will follow up on this thread with more information when I get it!

[snipsnsnails]

I believe these tests are accurate. However no test is 100% and there will be someone who gets the short end of the stick and fall in the 1%. I know my clinic which is very large had 2 that were inaccurate. I can't even tell you how many ended up being correct, it's a large number. Sorry yours was wrong or should I say congratulations!

[nuthinbutpink]

Just FYI- gender was just recently added to these tests. They didn't start out testing gender with any of these types of tests.

[WantingPink]

Thank you! I will be speaking with my midwives first thing this week, and following up with Sequenom as well, thanks to your suggestion. We saw lots of potty shots during the ultrasound, but did not get a printed one – the tech seemed to be lingering there for quite a while, probably because we told her Mat21 said boy. Foolishly, we didn't ask much at the time, feeling so sure of the Mat21 results (despite not seeing a penis!). We didn't get the female confirmation until the u/s report went to our midwife practice this weekend.

I will follow up on this thread with more information when I get it!

I hope you can get to the bottom of what happened and if you need suggestions or help feel free to ask. I am sorry this is happening!!

[HopeandDreamG]

Just FYI- gender was just recently added to these tests. They didn't start out testing gender with any of these types of tests.

That's strange since my test also offers the sex chromosomes test option, which includes the detection of Turner syndrome (Monosomy X), Triple X (XXX), Klinefelter syndrome (XXY), and Jacobs syndrome (XYY), the most common fetal sex chromosome abnormalities (also called sex chromosome aneuploidies). Sex chromosome aneuploidies are conditions in which there is a change from the usual 2 copies of sex chromosomes in males (XY) or females (XX).

[WantingPink]

That's strange since my test also offers the sex chromosomes test option, which includes the detection of Turner syndrome (Monosomy X), Triple X (XXX), Klinefelter syndrome (XXY), and Jacobs syndrome (XYY), the most common fetal sex chromosome abnormalities (also called sex chromosome aneuploidies). Sex chromosome aneuploidies are conditions in which there is a change from the usual 2 copies of sex chromosomes in males (XY) or females (XX).

The gender determination and sex chromosome abnormalities have not been recently added. MaterniT21 started offering gender determination around Sept 2012 and they collected data long before that they just didn't report it out to the patients (this is the validation data and where the 99.4% comes from). The sex chromosome abnormalities were being reported about Feb 2013 however, data on these were being collected long before that. Data is collected for awhile to get a statistically significant sample size and to capture the abnormalities they are testing for. In the last several months they have added 4 micro-deletions as well as two other trisomy tests.

[Mrs_Incredible]

That's strange since my test also offers the sex chromosomes test option, which includes the detection of Turner syndrome (Monosomy X), Triple X (XXX), Klinefelter syndrome (XXY), and Jacobs syndrome (XYY), the most common fetal sex chromosome abnormalities (also called sex chromosome aneuploidies). Sex chromosome aneuploidies are conditions in which there is a change from the usual 2 copies of sex chromosomes in males (XY) or females (XX).

I took that option with the harmony too. I'm hoping that 2 lots of testing, 1 for gender, and 1 for the sex chromosomes mentioned above mean that my test is correct as effectively a double check took place??
GL to the OP getting some answers xx


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[Girlfriend]

Is this test avail in Australia ? How much does it cost and how early can it be done?

[WantingPink]

From what I understand the test isn't offered in Australia. Maybe that has changed recently though??

Mrs. I that isn't really how the test works. From what I understand they are counting relative numbers of chromosomes so it is one test run that gives all the results.

[Mrs_Incredible]

Right, thanks. We opted to look at the sex chromosomes so am taking it as a good sign that they only found XX :)

[momtobe]

Hi there,
Did you ever figure out why your test was wrong? I just had this test completed and noone wants to give any more information why the incorrect tests occur.
I would appreciate if you can give us an update.
Thanks!

[atomic sagebrush]

I think that the tests are WAYYYYYY more accurate than ultrasounds and I would not be at all surprised to hear that this person ended up having what the blood test predicted.

PLEASE don't look for false hope from an Internet post when we're not even sure that the person is even legit, you know? If you got a Materniti21, Harmony, Panorama test, and didn't hear what you wanted to hear, the odds are sky high that you are not geting your desired gender. And this is true no matter how many posts you can dig up with people claiming that it didn't work for them on the basis of an ultrasound shot. Ultrasounds are wrong all the time, even ultrasounds that "should" be right. Techs are fallible and mistakes do happen.

I'm not saying any of these tests are 100% guarantees, but they ARE more reliable than ultrasounds, for the most part.

[atomic sagebrush]

Right, thanks. We opted to look at the sex chromosomes so am taking it as a good sign that they only found XX :)

Just to update, Mrs. I was told girl on her blood tests, ultrasound looked boy at first, and she really worried about it for her whole pregnancy. It was a girl!!

[Mrs_Incredible]

Atomics right! I read this post just after i got my harmony results, and it put a right damper on things! I had scans at 16, 17 (for gender because of it) and they did say girl, then 27 & 28 weeks for 4d and they confirmed girl. And my little girl arrived all girl ... It's still sinking in 10 weeks on, and on her birth day i was still worried it was wrong. The harmony result seemed too good to be true and this post didn't help my paranoia xx

[luckyfourleafclover]

does anyone know what happened to icefloe though? wonder if she had a boy or a girl?

[Mrs_Incredible]

She only poster twice, i doubt she will ever update xx

[atomic sagebrush]

Yes that is what I think too - she'll never come back and update, and in perpetuity people who desperately want to believe their blood tests are wrong, or fear that they are, are going to seize on this totally unproven thread and have false hope or false despair. :/

Always keep in mind, dear readers, we have no way to know if the people who post on forums are even telling the truth to begin with and when we don't hear the end of the story, please always take with a big grain of salt! :)

[Aimee13]

23107 WEll my Panorama dna test came back girl, But this gender shot, clearly looks boy at 22 weeks. Very confusing for me and the ultrasound tech! Whats are your thoughts??

[Aimee13]

23108 This shows my 24 week up close at the tip of the nub thing. It looks like a hotdog tip! I don't know exactly what to make of it?

[Kittybear]

Is this a potty shop Hun? I maybe see what you mean but that zoomed in it is hard to tell what I'm looking at.

Are you having another scan to see baby's gender? Maybe go back to the blood test lab with your scan photo? Sorry for the confusion you are going through! X

[Kittybear]

*shot* not shop! Stupid predictive text on phone! X

[Aimee13]

The tech took a upclose picture of the genital area. The baby won't cooperate for a potty shot because it just lays on its back and spreads its legs! Since the Panorama test came back girl, I feel like I don't know what to believe at this point. I go back again in two weeks! Ugg the waiting forever to know for sure. I don't see how this could be a girl genital part at 24 weeks?

[True Blue]

How frustratingly confusing for you!!

[atomic sagebrush]

22 and 24 weeks are not as good for nubs, you'd need a potty shot. I don't see anything on either of those tests that tells me anything.

I"m seriously not saying these tests are flawless and can never be wrong, but we all KNOW ultrasounds are NOT flawless and are wrong all the time, and in my opinion and experience, blood tests > ultrasounds.

[Aimee13]

I guess I will get a surprise when the baby is born, if in two weeks, The baby still won't cooperate! LOL thanks for your thoughts!

[atomic sagebrush]

If you have a preference, I hope you get what you're wishing for!

[maidentomother]

Blood tests, especially the Panorama >>>>> ultrasounds! Aimee, I can't imagine how frustrated you must be. I hope you get a decisive look in 2w. I agree that nothing in those very low quality images you posted suggests boy parts at all. I am personally planning (if ever I conceive) on only having a scan at 13w and Panorama blood work at 9w, and if the results are normal, I won't get any further ultrasounds.

[Aimee13]

Thanks much ladies for your info. Since I already have 8 girls, one more wouldnt matter! Panorama showed baby is without defects but it's always fun to guess! My son turns two Saturday so a girl would be fine to! Good luck Maidentomother, never give up!

[Mrs_Incredible]

Aimee, let us know how you get on :) xx

[momtobe]

Aimee, I am 100% sure you are having a gorgeous baby girl! Don't worry about the ultrasound pictures. They are never clear and some techs are just not experienced enough.

[atomic sagebrush]

Can I just point out that most of the people who show up claiming these tests didn't work for them, never come back to update???

We are now several years on with these tests and I can say pretty definitively - THEY WORK. By far and away more reliable than ultrasounds. PLEASE please ladies, do not go looking up these old threads and allowing them to give you false hope OR false despair. Your blood test is almost certainly correct.

[XXforhubby]

This worked for me- told boy at 10 weeks and am rocking my sweet DS3 as we speak [emoji4]!!


DS1[emoji125]🏼, DS2[emoji577], DS3[emoji170][emoji577][emoji843][emoji602][emoji170]