Gendersure embryos

[coralsky]

Hi Dr P,

I originally asked this question a while ago in the ivigen forum (while it was there) but unfortunately it went unanswered, and it occurred to me that you may know the answer....

I am curious as to whether there have been any embryos that you have tested using GenderSure (which as I understand is the addition of an extra PCR test to "confirm" the gender result of aCGH... I hope this is correct?) in which the PCR test has "disagreed" with the gender result of the aCGH testing?... if so, how many embryos (numbers and/or percentage) has this happened with... I would imagine that if there have been any, it would be a very small number? But it would be very interesting to know the specifics.

Many thanks in advance :)

[Dr. Potter]

Hi
Sorry for the delay. The overall reported accuracy for aCGH is always reported as 98%. This is not specific to the sex chromosomes and as most errors are not viable, the actual observed rate is <1%. Regarding GenderSure specifically the answer is complex. The short answer is about 1/150 the long answer is that not always are these discrepancies otherwise normal/viable. Hope this helps.
Best,
Dr Potter