Day 3 accuracy of aCGH for gender
Hi Alyssa!
Let me preface my question with the background knowledge that we have had people give birth to opposite gender children on here after using day 3 CGH. It was over a year ago when it happened but it has happened and since then, we as a community looked into the issue and tried to go right to the source- Dr Sher of SIRM who is responsible for the aCGH test. He told us that Day 3 aCGH is not always reliable for gender detection because the "Y" chromosome is so small, during the analysis, the "computer" does not see it and since CGH does not actually look for 2 XX chromosomes and compares DNA found to a sample, it incorrectly can label the embryo as a normal XX embryo when in fact it is a normal XY- that is my "non-medical background" synopsis!
SO, we have people consult with doctors that say they use day 3 aCGH when doing 23+gender testing and they think it is just fine to use. Many clinics have gone to day 5 only because as we have also seen on here, embryos that initially test "abnormal" with day 3 testing can retest normal on day 5 with a re-biopsy and have resulted in pregnancies on here. That is compelling enough for me to not use day 3 testing but when people are trying to choose clinics, not all clinics have day 5 biopsy capability and then travel becomes as issue and it just makes the process hard.
My questions-
1. How reliable in your opinion is day 3 aCGH testing- particularly for gender.
2. Is day 5 testing done using one cell just like day 3 with aCGH? If so, is it any more reliable than day 3?
2 things that sway my opinion with Day 3 CGH from Dr Sher of SIRM-
Array CGH vs. Metaphase CGH in IVF: Which is Best & When to Test | IVF Authority
and
http://genderdreaming.com/forum/ivf-...h-testing.html
Thanks!!