x2 cancelled cycles due to OHSS risk should I give up?

Hi Dr P
I have tried ivf/pgd twice now and over stimulated both times 45+ follicles. I have polycystic ovaries but without the full syndrome. I have 3 boys 14,12 & 3. This last cycle in June I was down regulated for 3 weeks then on 150iu merinol alternated with 75iu each day and still over responded!! Could you help???:DD:

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Originally Posted by Allguys

Hi Dr P
I have tried ivf/pgd twice now and over stimulated both times 45+ follicles. I have polycystic ovaries but without the full syndrome. I have 3 boys 14,12 & 3. This last cycle in June I was down regulated for 3 weeks then on 150iu merinol alternated with 75iu each day and still over responded!! Could you help???:DD:

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You need to be tested for insulin resistance if you haven’t been already. Metformin can often help normalize the response. A couple other approaches that can be useful in such situations is either an antagonist cycle with lupron trigger or a long antagonist cycle where you are completely shut down with antagonist prior to stim. Both of these approaches can be combined with all freeze if need be. There is always a way to work around this in my experience.