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I suppose for some people it might be significant. I won't know as we are team green, but my pregnancies with the girls were carbon copies, and I had much much less nausea (as long as I snacked I was feeling great). With the girls, if I had a chance to get zofran, I would have done it in a heartbeat because I was so desperate.
My first pregnancy was a girl and that was horrible had to be put on medication, both ds's were similar just a bit of dizziness and dd2 while i was a little more sick than with the boys still wasnt as bad as dd1 so i wouldnt guess based on symptoms. I also have a cousin that threw up 9 months with her ds1 and not once with ds2 so you never know.