Here is the drugs.com link to their Clomid page:
http://www.drugs.com/pro/clomid.html
According to the Advanced Fertility Centre of Chicago’s webpage , Clomid causes hostile CM in about 30% of women for whom it is prescribed, which means that 70% of women will not see an adverse effect on CM.
My own FS explained to me that thinning of the uterine lining is considered a serious side effect of Clomid, right up there with OHSS, and would result in immediate cancellation of the protocol and a shift to injectables. It is NOT common and is usually associated with prolonged use. Every FS I have ever spoken to has been reluctant to keep a woman on Clomid for more than 3 cycles and none would prescribe it after 6 – there is a reason we need a prescription for this stuff ladies. If you’re on it, you need to be monitored, preferably with regular v/us and blood tests to ensure that it’s doing with it’s supposed to (and nothing else).
The studies that found Clomid to shift the sex ratio are based on older research before injectables became part of the main******. I can’t find it now, but I read a study a couple of months ago showing that Clomid has no effect on gender ratio if it’s use is well monitored and only prescribed for a short time.
With regard to the safety issue...
It is important to keep in mind that Ob/Gyns are NOT trained in reproductive endocrinology, though few would rush to point this out. Here is a link to the American Society for Reproductive Medicine’s page on the steps a practitioner has to follow to become a certified FS:
http://www.asrm.org/detail.aspx?id=1909
As the site explains, in addition to qualifying as an Ob/Gyn, an FS has to complete 2 to 3 EXTRA YEARS of fellowship training to be recognised and this holds true in just about every country where fertility treatments are offered. In the US that's 4 years premed, 4 years med school, 4 years of Ob/Gyn residency and 2 or 3 more years of RE fellowship. Though it may not seem like much, those 2 to 3 extra years make a BIG difference in a practitioner's knowledge of the reproductive system and what to do when it gets wonky.
Even in the medical community there are a lot myths and misconceptions regarding Clomid. It IS a safe drug if used appropriately, but the cold hard truth is that doctors are only human and many of them simply don’t bother to keep track of the newest studies on the meds they prescribe. If you are taking it, then it is really important that you educate yourself and ask the hard questions when talking to your doctor.
Sorry for preaching, but I think its important for people to be aware of this.