Is there any explanations to abnormal embryos?
Dear Carole Wegner
Earlier this month I did my first IVF/PDG-cycle in Europe and all my five tested embryos came back with abnormal genetic analysis after PGS array-CGH-testing. Is there any explanations to why this happened?
I am 40, no history of infertility, 3 healthy sons. Had good pretesting. AMH: 11.9, FSH: 6.9, LH: 7.8. 13 eggs retrieved. 8 fertilized. 5 was biopsied on day 5/6 and frozen.
My hubby has low morphology (1 pct.) but very high numbers on all other semen-values. We used frozen s. I took all the recommended vitamins and dietary supplements including DHEA and melatonin. My protocol was 225 Gonal-f for 12 days, Orgalutran and Ovitrelle as trigger.
The abnormal embryos were all grade 2 HB and FHB, but had following problems:
- one (XX) had gain of chromosomes 9, 21 and susp. partial gain of chromosome 11q.
- another one (XY) had susp. partial gain of chromosome 16p in mosaic.
- another one (XX) had gain of chromosomes 20 and susp. loss of chromosome 8 end 9 in mosaic.
- another one (XX) had multiple chromosomal abnormalities.
- the last one (XY) had susp. partial loss of chromosome 17p.
Am I unable to produce healthy embryos because of my advanced maternal age? Is it just bad luck? Could it be a lab-issue and that the embyo could be re-biopsied and turn out to be normal? Or could it be other factors such as emotionel stress during stim-period (a close relative of mine was about to die during this proces)?
I know you have answered this kind of question several times before, but I would really accpreciate if you have time to write some words.
Thank you so much in advance.