Dr. Sher's Advice about Day 3 CGH Testing
So, I went on Dr. Sher's blog and posted a comment to him about the 2 opposites and the use of day 3 CGH that apparently caused them. Here is his response:
"I have repeatedly cautioned that day-3 array CGH (aCGH) is fraught with issues. This probably proves my point. The amount of DNA in a single cell is so minute that you aCGH is unreliable. Metaphase CGH done correctly would not make such an error. I urge you to read the blog I posted elsewhere on this site, comparing mCGH with aCGH for PGD. FISH should be accurate but it does not access all chromosomes so, while gender determination would be reliably, assessment of embryo quality falls far short of the mark."
Geoff Sher
So, PLEASE make sure that you NEVER use day 3 aCGH for GS purposes.