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  1. #1
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    Lupron (Lucrin) vs Ganirelix

    I've just had a failed cycle using Lupron, and my RE wants to replace it with Ganirelix. However, I've read that Ganirelix tends to produce fewer oocytes and lowers implantation rates...what should I do?

  2. #2
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    Quote Originally Posted by Jaybz View Post
    I've just had a failed cycle using Lupron, and my RE wants to replace it with Ganirelix. However, I've read that Ganirelix tends to produce fewer oocytes and lowers implantation rates...what should I do?
    I would ask the RE what the rationale is for the change. Was the quality bad? There are sometimes tradeoffs that are worthwhile. If you had a HB negative, I would also consider a reevaluation of the uterine cavity.
    Daniel A. Potter, MD
    Medical Director, HRC Fertility Newport Beach, California
    Laboratory Director, Natera (formerly Gene Security Network)
    http://www.amazon.com/What-When-You-...keywords=hanin
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  3. #3
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    Quote Originally Posted by Dr. Potter View Post
    I would ask the RE what the rationale is for the change. Was the quality bad? There are sometimes tradeoffs that are worthwhile. If you had a HB negative, I would also consider a reevaluation of the uterine cavity.
    Thanks Dr. Potter. The quality was not bad, but he thought that Lupron oversuppressed me, as stims went on longer than normal. His rationale is to aim for a higher number of good quality eggs. I've had a sonohysterogram, and nothing suspect came up.

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    Quote Originally Posted by Jaybz View Post
    Thanks Dr. Potter. The quality was not bad, but he thought that Lupron oversuppressed me, as stims went on longer than normal. His rationale is to aim for a higher number of good quality eggs. I've had a sonohysterogram, and nothing suspect came up.
    Implantation rate for hatched blasts was 90% for my series 2010 to date. That is why I would start to consider that perhaps something else is going on.
    Daniel A. Potter, MD
    Medical Director, HRC Fertility Newport Beach, California
    Laboratory Director, Natera (formerly Gene Security Network)
    http://www.amazon.com/What-When-You-...keywords=hanin
    http://www.danielapottermd.com
    @ivfgenderselect

  5. #5
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    Quote Originally Posted by Dr. Potter View Post
    Implantation rate for hatched blasts was 90% for my series 2010 to date. That is why I would start to consider that perhaps something else is going on.
    Is that for GSN tested embryos? I only did 3 probe, so it's possible that the blast didn't continue to progress or implant.

  6. #6
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    Quote Originally Posted by Jaybz View Post
    Is that for GSN tested embryos? I only did 3 probe, so it's possible that the blast didn't continue to progress or implant.
    This is with GSN. With SET GSN is particularly helpful. I would strongly recommend it if you are planning another SET.
    Daniel A. Potter, MD
    Medical Director, HRC Fertility Newport Beach, California
    Laboratory Director, Natera (formerly Gene Security Network)
    http://www.amazon.com/What-When-You-...keywords=hanin
    http://www.danielapottermd.com
    @ivfgenderselect

  7. #7
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    Quote Originally Posted by Dr. Potter View Post
    This is with GSN. With SET GSN is particularly helpful. I would strongly recommend it if you are planning another SET.
    I was planning on putting 2 embryos back after GSN, but my low egg numbers swayed me towards 3 probe in order to avoid no transfer after traveling so far. If I have higher egg numbers this time, I'll probably go with GSN. Thanks Dr Potter!

  8. #8
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    Quote Originally Posted by Jaybz View Post
    I was planning on putting 2 embryos back after GSN, but my low egg numbers swayed me towards 3 probe in order to avoid no transfer after traveling so far. If I have higher egg numbers this time, I'll probably go with GSN. Thanks Dr Potter!
    Good luck
    Daniel A. Potter, MD
    Medical Director, HRC Fertility Newport Beach, California
    Laboratory Director, Natera (formerly Gene Security Network)
    http://www.amazon.com/What-When-You-...keywords=hanin
    http://www.danielapottermd.com
    @ivfgenderselect

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