Hi Carole,
Is the microarray PGD the same as CGH?
Thank you,
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Thread: PGD and CGH?
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October 25th, 2011, 11:57 AM #1Dream Vet
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October 25th, 2011, 06:32 PM #2Dreamer
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Basically yes. Microarray is also called array comparative genome hybridization (a-CGH). This technique can be used in various research applications, preimplantation genetic diagnosis (aka. PGD) is just one application. People often use PGS and PGD interchangeably but they are different. PGD is used to DIAGNOSE (hence the D in PGD) a genetic mutation in a single gene that causes disease. PGS is used to SCREEN for more common problems affecting large pieces of DNA like chromosomes - having the wrong quantity of a particular chromosome (aneuploidy) or if pieces of chromosome are swapped end to end (translocations), these can be picked up by PGS. Gender selection is a kind of PGS, not PGD. More than you asked for I know!
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October 31st, 2011, 09:27 AM #3
That is interesting, thank you Carole. So technically we should be using the term PGS.
DS1+ DS2
IVF/PGD (3 probe PCR + ICSI). BCP; Lucrin; Puregon (125). ER 31/08: 20 - 19 Mature - 14 Fertilized.
Total of 5 HB embryos sent for PGD. Results: 3 XY + 2 XX OHSS risk = NT. 1st Natural FET 08/11/11.
1st POAS 7dp5dt= BFP. 1st Beta 10dp5dt = 226; 2nd Beta 13dp5dt = 988; 3rd Beta 17dp5dt = 4392
1st U/S 6w1d HB 113bpm. 2nd U/S 7w6d HB 165bpm
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November 15th, 2011, 03:12 PM #4Dream Vet
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