In Vitro Fertilization Protocol Using Ganirelix or Cetrotide
The sample schedule below is for IVF stimulation using GNRH antagonist medications to prevent premature ovulation during the cycle.
- Two GnRH antagonist medications are currently used in IVF protocols in the US – Ganirelix acetate and Cetrotide.
- GnRH antagonist drugs bind to receptors for GnRH hormone in the pituitary.
- This prevents the pituitary from releasing LH and FSH hormones (temporarily).
- GnRH antagonist in vitro fertilization cycles involve less injections as compared to Lupron down regulation or Lupron flare IVF protocols.
The antagonist outline below shows a schedule with timing of drugs, approximate timing of ovarian stimulation monitoring, and IVF procedures.
Blood and ultrasound – follicles now are ready
HCG trigger shot at night
Ganirelix (Antagonist) IVF Protocol Calendar
USING BIRTH CONTROL PILLS
Day 1 – Last BCP pill after about 3 weeks on
Day 2-5- Rest
Day 6 – Baseline blood and ultrasound- Start FSH injections
Day 7-9 – Continue FSH Injections
Day 10 – (day 5 os stims) – Bloodwork and ultrasound check
Day 11 – (day 6 of stims) – start Ganirellix
Day 12 – Bloodwork and ultrasound check – Continue Ganirellix
Day 13 -14 – Continue Ganirellix
Day 15 – Day 10 of stims – Bloodwork and ultrasound check – follicles now are ready, HCG (Trigger shot that night)
Day 16 – Rest
Day 17 – Egg Retrieval Day
Day 18 – Start progesterone
Day 19 – Biopsy day for PGD
Day 20-21 – Continue progesterone
Day 22 – Embryo Transfer Day
Day 32- Blood Pregnancy Test (10dp5dt)