Thread: Biopsy timing question
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December 22nd, 2010, 08:37 PM #1spriteGuest
Biopsy timing question
Hi Dr Potter and Lori. I have wanted to ask a question for a while but you had to be a gold member and it was broken on the other site so I could never ask.
I have lurked a lot in the past and learned a lot reading but I still have some questions.
It seems that most of the embryos are abnormal no matter hold old one is. My question is about the biopsy and timing. If the cellls are constantly changing and chromosomes are multiplying, how does the embryologist time the biopsy?
If the cell is about to split, wouldn't it look like there are abnormalities at that point if you grabbed that cell?
I don't know the science of it all so I may just not understand how it works! Thanks!
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December 23rd, 2010, 02:24 PM #2
I have been wondering the same thing since I got my PGD results back. Good question!
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December 23rd, 2010, 07:16 PM #3Moderator
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When cells are dividing, the chromosomes decondense and the nucleus is not visible. We only send cells for analysis that have a nucleus visualized.
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December 24th, 2010, 11:46 AM #4IVF Advice Coach
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Just so I understand, so if you have a cell come back with no nucleus, is it possible that the cell was just diving and may be normal? Is that one you would re-biopsy on day 5 with GSN?
Mom to
and my IVF/PGD
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December 24th, 2010, 01:54 PM #5
Good question NBP. I had 5 embryos come back with no nuclei.
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December 29th, 2010, 10:04 AM #6
Good question NBP. I hope we get any feedback soon on this.
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December 30th, 2010, 04:06 PM #7IVF Advice Coach
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Dr Potter and Lori are on vacation- most REs are over the holidays. I expect them back after the weekend. Kind of bad timing with the site launch but they will be here on a regular basis- Lori just emailed me last night.
Mom to
and my IVF/PGD
It's better to look back on life and say: "I can't believe I did that" than to look back and say "I wish I did that".
New to IVF/PGD for Family Balancing? Read this- Understanding IVF/PGD- a HT Guide for those New to the IVF/PGD Process
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January 2nd, 2011, 03:24 PM #8Moderator
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Yes. When there is 'no nucleous' it means basically 'no result'. This indicates that either the amplification of the DNA failed or that the cell did not contain any DNA. Either way it is the equivalent to not having any results at all. The majority of the embryos where there is a 'no result' do not continue to divide and so are not candidates for re-biopsy on day 5. This is because the 'no results' is often indicative of disordered cell division. In cases where 'no results' embryos keep dividing and make it to the blastocyst stage, re-biopsy can be performed.
Daniel A. Potter, MD
Medical Director, HRC Fertility Newport Beach, California
Laboratory Director, Natera (formerly Gene Security Network)
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http://www.danielapottermd.com
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