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Archive for Elective IVF for Gender Selection – Page 8

High Tech Methods of Gender Selection

by nuthinbutpink
December 8th, 2010

The American Society for Reproductive Medicine has ruled that it is proper and ethical to help couples to choose the sex of their babies.  This board is dedicated to discussing gender selection for family balancing purposes.  Clinics that provide Gender Selection do so with the goal of family balancing and unless there is a genetic reason, Gender Selection is typically not available for someone wanting a first child of a certain gender.

High Tech Gender Selection options are comprised of the following:

PGD with IVF:$14,000-20,000- ONLY CURRENT AVAILABLE OPTION FOR GENDER SELECTION

Preimplantation Genetic Diagnosis(PGD) or Preimplantation Genetic Screening(PGS)  is the process of taking a single cell from an embryo on day 3 of  culture and analyzing the chromosomes for its genetic makeup, including gender. This process is carried out via FISH or GSN.

Pros: Guarantee of gender, potentially rule out major causes of miscarriage, can be performed all over the US- anywhere that offers GS, no/lower travel costs and away time, no semen analysis required, higher pregnancy rate than IUI, (most of us are told 60% chance with 2 blasts, 40% with one), about the same cost as MS/IVF

Cons: Risk of no transfer due to no desired gender available, risk of no transfer due to all abnormals, do not have the option of a day 3 transfer b/c gender is unknown at that time, need a decent amount of embryos to have a good chance although you can get lucky with lower numbers, embryos need to make it to day 5 for transfer, worries of PGD

MS + PGD + IVF:$17,000-25,000

Pros: Gender guarantee and strong health potential depending on how many probes selected, pregnacy rate higher than IUI(60% chance with 2 blasts, 40% with one), can be performed anywhere but fresh sample might be better for MS, higher likelihood of right gender available at transfer, have the option of a day 3 transfer if needed/recommended

Cons: NOT CURRENTLY AVAILABLE – Most expensive option, must go to CA or VA for fresh MS, longest time away from home, potentially highest travel expenses, the more “procedures” you add to IVF, the more potential obstacles to overcome, good SA is required, not available to everyone due to trial restrictions, risk of all abnormal/no transfer is there, embryos must survive until day 5 for PGD results, worries of PGD and MS, Cannot ship frozen MS embryos out of the US

MicroSort with IUI: $3800-5000

MicroSort®

MicroSort® is an exclusive preconception sperm sorting technology, developed by the Genetics & IVF Institute (GIVF), that is designed to increase the likelihood of conceiving a child of a particular gender. GIVF conducted a clinical trial using the MicroSort® technology. This research study used MicroSort®’s patented technology, which is designed for the purpose of separating sperm either into those that primarily produce girls or those that primarily produce boys. The purpose of the research study was to investigate the safety and effectiveness of conceiving a child of the indicated gender to either: 1) prevent genetic disease or 2) facilitate family balancing.  Preliminary findings from GIVF’s study data so far indicate that for patients sorting sperm for a girl baby, approximately 9 out of 10* of those who became pregnant were successful in conceiving a female baby; for those sorting for a boy baby, approximately 3 out of 4* who became pregnant were successful in conceiving a male baby.  The U.S. Food and Drug Administration (FDA) has not reviewed these results and has not determined whether MicroSort® is safe or effective.  MicroSort new enrollment is limited to couples attempting to prevent sex linked or sex limited disease by using MicroSort® sorted sperm. It is NOT enrolling new patients for family balancing purposes.

 Pros: Least invasive of all HT.  Least expensive option too.  Pretty good chance at getting the right gender, if you achieve pregnancy. Least amount of travel/stay time if you have/choose to travel for HT.

Cons:  NOT CURRENTLY AVAILABLE – Lowest pregnancy rates(average of 16% depending on what type of meds are used according to the MicroSort website), no guarantee of gender(1 in 10 will get an opposite for XX), DH has to pass a Semen Analysis to qualify, other restrictions like age on who can be in the trial, only offered in 2 locations(VA or CA), worries of MS technology

MicroSort with IVF: $14,000-20,000

Pros: Likelihood of transfer is high, can transfer on day 3 if one chooses, can use frozen or fresh sample so can be done in a number of locations, odds of pregnancy are good if one has 2 blasts to transfer

Cons: NOT CURRENTLY AVAILABLE – No gender guarantee, not cheap(IVF plus MS fee), for best results, it has been suggested to travel to VA or CA to have it done with fresh MS, will not know if embryos have any genetic issues that PGD might discover had that been performed so if you have 10+ embryos to choose from, you could potentially end up with doing several cycles with FETs and still not achieve pregnancy, might need to transfer more than you would had you done PGD due to unknown health and day 3 transfer, worries of MS, Cannot ship frozen embryos out of the US so any/all FETs have to be done on US soil

Categories Elective IVF for Gender Selection
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Slow Growing Embryo? Likely a GIRL!

by nuthinbutpink
December 8th, 2010

Faster growing embryos resulted in more male births and slower growing embryos resulted in more females

 It was found that if you transfer an embryo that has a total number of cells less than the mean in the total number of embryos, then there is a very large increase in the number of female births (88.8% of births being female). If in fact you transfer an embryo that has a number of cells greater than that mean in the total number of embryos available for transfer, then the situation is reversed and you observe 90% of offspring being male.

Tarrin et al(1995) have discussed whether in fact in vitro selection programs carried out around the world may in fact be inadvertently affecting the ratio of female to male babies. In this study, three groups of IVF patients were described based on the number of cells present in the embryo transferred relative to the mean number of cells in all embryos that were ready for transfer. It was found that if you transfer an embryo that has a total number of cells less than the mean in the total number of embryos, then there is a very large increase in the number of female births (88.8% of births being female). If in fact you transfer an embryo that has a number of cells greater than that mean in the total number of embryos available for transfer, then the situation is reversed and you observe 90% of offspring being male.

So by selecting for fast cleaving embryos, those that have high numbers of cell divisions, and slow cleaving embryos, those that have a low number of cell divisions, it is possible to affect the sex ratios in the subsequent offspring (Tarrin et al, 1996). A second finding is that in fact maternal age has an effect on the ratio of male to female offspring. It was found that in patients below 35 years of age, 62.7% of births were males and in patients above 35 years of age 71.4 were female. So clearly these results would suggest that by selecting slow cleaving(slow dividing) and rapidly cleaving( fast dividing) embryos and by maternal age, it is actually possible to affect the ratio of female to male babies born through in vitro fertilization.

Source:  Tarin JJ, Bernabeu R, Baviera A, Bonada M, Cano A Sex selection may be inadvertently performed in in-vitro fertilization-embryo transfer programmes. Hum Reprod 10 (11): 2992-2998 (Nov 1995)

Categories Articles, Elective IVF for Gender Selection

Researchers Develop Test to Identify ‘Best’ Sperm

by Gender Selection Guru
November 30th, 2010

ScienceDaily (May 31, 2010) — Researchers at Yale School of Medicine have discovered a method to select sperm with the highest DNA integrity in a bid to improve male fertility. The method is comparable to that of the egg’s natural selection abilities, according to the study published in the June/July issue of the Journal of Andrology.

“Our results could help address the fact that approximately 40 percent of infertility cases can be traced to male infertility,” said the senior author of the study, Gabor Huszar, M.D., director of the Sperm Physiology Lab and senior research scientist in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale.

Huszar said that past semen analysis focused on sperm concentration and motility. It was assumed that if a man had a high sperm count and active sperm, that he was fertile. But there was no information on the sperm’s fertility or its ability to attach to its mark, the female gamete. In an ideal case, the egg naturally selects the optimal sperm, but during in-vitro fertilization treatment of men who had only a few sperm, clinicians did not know whether they were injecting the correct sperm into the egg for fertilization. “We have now found a biochemical marker of sperm fertility so that we can select sperm with high genetic integrity,” Huszar said.

Huszar and his colleagues tested the idea that binding sperm to hyaluronic acid selects sperm with high DNA integrity. They studied semen samples from 50 men, and a part of the sperm in the semen was allowed to bind to hyaluronic acid. These sperm were isolated, and the DNA chain integrity was compared to the original sperm in semen. The team used a reagent that stained sperm with high DNA integrity green, whereas sperm with fragmented DNA, and diminished DNA integrity were stained red.

“The sperm with fragmented DNA work like scratched CDs,” Huszar said. “They seem to be operational, but when you play them, some of the information is missing. These damaged sperm may also carry chromosomal aberrations that could be related to genetic diseases.” Huszar and his colleagues identified the nuclear and cytoplasmic attributes of various sperm. They also identified a key relationship between the ability of sperm to bind to hyaluronic acid and between high sperm genetic integrity, which enhances the sperm’s contribution to normal embryo development.

“When sperm is selected with hyaluronic acid binding, they are of comparable, if not better, overall quality than sperm chosen by the oocyte in the natural fertilization process,” said Huszar.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.


[1] Yale University (2010, May 31). Researchers develop test to identify ‘best’ sperm. ScienceDaily. Retrieved December 8, 2010, from http://www.sciencedaily.com­ /releases/2010/05/100528211202.htm

Categories Elective IVF for Gender Selection
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